Description

3-(2,2-Difluoroethoxy)Benzoic Acid is a high-purity, fluorinated benzoic acid derivative characterized by its unique difluoroethoxy side chain. This compound serves as a critical pharmaceutical intermediate and advanced organic building block for synthesizing complex molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorine motifs for enhanced bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for drugs targeting metabolic and central nervous system disorders.
• Agrochemical Synthesis: Building block for developing new-generation herbicides and fungicides where the difluoroethoxy group can improve lipophilicity and systemic activity.
• Liquid Crystal Materials: Used in the research and production of fluorinated liquid crystals for advanced display technologies.
• Organic Electronics: Serves as a monomer or dopant in the development of organic semiconductors and electro-optical materials.
• Chemical Research: Valuable reagent in medicinal chemistry and process R&D for structure-activity relationship (SAR) studies and scaffold diversification.
• Fluorine Chemistry: A versatile synthon for introducing the 2,2-difluoroethoxy moiety into more complex molecular architectures.

Basic Information

Product Name	3-(2,2-Difluoroethoxy)Benzoic Acid
CAS No.	812700-19-9
Molecular Formula	C9H8F2O3
Molecular Weight	202.16 g/mol
Synonyms	3-(2,2-Difluoroethoxy)benzoic acid; Benzoic acid, 3-(2,2-difluoroethoxy)-; 2,2-Difluoroethyl 3-carboxyphenyl ether; 3-Carboxy-2,2-difluoroethoxyphenyl; 3-(Difluoroethoxy)benzoic acid; 3-(2,2-Difluoroethoxy)benzoate; DFEOBA (abbreviation)
EINECS	Contact for details

Quality Control

Our 3-(2,2-Difluoroethoxy)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption. Keep away from strong oxidizers and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.