Description

3,5-Difluoro-4-(2,2,2-trifluoroethoxy)benzoic acid is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound is critical for introducing specific fluorine and trifluoroethoxy motifs into target molecules, significantly altering their physicochemical and biological properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and anti-cancer drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine atoms enhance lipophilicity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in high-performance displays.
• Polymer Chemistry: Acts as a monomer or modifier for synthesizing specialty polymers with enhanced chemical resistance and unique surface properties.
• Organic Electronic Materials: Employed in the synthesis of electron-transport materials and semiconductors for OLEDs and organic photovoltaics.
• Chemical Research & Development: A versatile building block for medicinal chemistry, enabling structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	3,5-Difluoro-4-(2,2,2-trifluoroethoxy)benzoic acid
CAS No.	801303-45-7
Molecular Formula	C9H5F5O3
Molecular Weight	256.13 g/mol
Synonyms	4-(2,2,2-Trifluoroethoxy)-3,5-difluorobenzoic Acid; 3,5-Difluoro-4-(2,2,2-trifluoroethoxy)benzoic Acid; Benzoic acid, 3,5-difluoro-4-(2,2,2-trifluoroethoxy)-; 801303-45-7; 3,5-Difluoro-4-trifluoroethoxybenzoic Acid
EINECS	Contact for details

Quality Control

Every batch of 3,5-Difluoro-4-(2,2,2-trifluoroethoxy)benzoic acid is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemicals and advanced intermediates. A comprehensive Certificate of Analysis (COA), detailing purity, identity, and impurity profiles as determined by HPLC, NMR, and MS, is provided with each shipment to guarantee consistent quality and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. Due to its nature as a strong acid/organic solvent, handle with appropriate personal protective equipment in a fume hood.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.