Description

Dabsyl-L-Leucine is a high-purity, chromophore-labeled derivative of the essential amino acid L-leucine, widely recognized under the CAS registry number 89131-12-4. This compound is a critical reagent in advanced analytical chemistry, valued for its excellent UV absorption and fluorescence properties which enable highly sensitive detection. It is primarily utilized by research institutions, pharmaceutical developers, and quality control laboratories involved in amino acid analysis, proteomics, and peptide sequencing.

Application

• Amino Acid Analysis: Acts as a pre-column derivatization agent for the sensitive HPLC or UHPLC analysis of amino acids, enabling precise quantification in complex biological matrices.
• Proteomics Research: Used in peptide mapping and protein sequencing workflows to label and detect N-terminal amino acids, facilitating structural elucidation.
• Pharmaceutical QC: Serves as a reference standard and derivatization standard for the quality control of peptide-based drugs and parenteral nutrition formulations.
• Biochemical Assay Development: Employed in the development of fluorometric and spectrophotometric assays for enzyme activity (e.g., proteases, peptidases) and metabolic studies.
• Food & Feed Analysis: Applied in the accurate determination of amino acid content and profile in nutritional products, ensuring compliance with labeling and safety standards.
• Diagnostic Reagent Manufacturing: Incorporated into kits and reagents for clinical diagnostics, particularly for inborn errors of metabolism screening.

Basic Information

Product Name	Dabsyl-L-Leucine
CAS No.	89131-12-4
Molecular Formula	C18H23N3O4S
Molecular Weight	377.46 g/mol
Synonyms	4-Dimethylaminoazobenzene-4'-sulfonyl-L-leucine; DABS-L-Leu; Dabsyl-Leucine; L-Leucine, N-[4-[(4-dimethylamino)phenyl]azo]benzenesulfonyl]-; N-Dabsyl-L-leucine; DABS-Leu; Dns-Leu (historical); DABS chloride derivative of L-leucine
EINECS	Contact for details

Quality Control

Our Dabsyl-L-Leucine is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	Yellow to orange-yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.