Description

Poly(5-Fluoro-2'-Deoxyuridylic Acid) is a synthetic polynucleotide analog, specifically a polymer of the modified nucleoside 5-fluoro-2'-deoxyuridine monophosphate. This compound is of significant interest in biochemical and pharmaceutical research due to its role as a chain terminator and inhibitor of DNA synthesis. It is primarily utilized by research institutions and pharmaceutical developers engaged in oncology research, antiviral drug discovery, and molecular biology studies. The material is supplied with a high degree of purity to ensure reliable and reproducible experimental results.

Application

• Biochemical Research: Used as a specialized substrate or inhibitor in enzymatic studies, particularly those involving DNA polymerases and thymidylate synthase.
• Oncology Research: Serves as a critical tool for studying the mechanisms of fluoropyrimidine-based anticancer agents like 5-fluorouracil (5-FU).
• Antiviral Drug Development: Investigated for its potential to inhibit viral DNA replication in the development of novel therapeutic agents.
• Molecular Biology: Employed in controlled experiments to understand nucleic acid metabolism, chain termination, and polymerase fidelity.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Academic Studies: Utilized in university and institutional labs for advanced teaching and research in medicinal chemistry and biochemistry.

Basic Information

Product Name	Poly(5-Fluoro-2'-Deoxyuridylic Acid)
CAS No.	88410-68-8
Molecular Formula	(C10H12FN2O8P)n
Molecular Weight	329.18 (monomer unit)
Synonyms	Poly(5-fluoro-2'-deoxyuridylic acid); Poly(5-F-dUMP); 5-Fluorodeoxyuridylic Acid Polymer; Poly(5-fluoro-2'-deoxyuridine 5'-monophosphate); Poly(FdUMP); Poly(5-fluoro-dUMP); 5-Fluoro-2'-deoxyuridylic Acid Homopolymer; Poly(5-fluoro-2'-deoxyuridine phosphate)
EINECS	Contact for details

Quality Control

Our Poly(5-Fluoro-2'-Deoxyuridylic Acid) is manufactured under controlled conditions to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for assay and purity, spectroscopy for structural confirmation, and tests for residual solvents and moisture. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95%
Purity (HPLC)	≥ 98%
Moisture (KF)	≤ 5.0%
Solvent Residue (GC)	Meets ICH guidelines
Endotoxin	< 10 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.