Description

N2-Isobutyryl-3',5'-o-(1,1,3,3-Tetraisopropyl-1,3-Disiloxanediyl)Guanosine is a high-purity, protected nucleoside derivative essential for advanced oligonucleotide synthesis. This compound matters because it provides critical protection for the guanosine base and ribose sugar during automated solid-phase synthesis, enabling the production of high-fidelity RNA and DNA sequences. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and CROs engaged in the development of antisense oligonucleotides, siRNA therapeutics, and diagnostic probes.

Application

• Solid-Phase Oligonucleotide Synthesis: Serves as a key phosphoramidite building block for the automated synthesis of RNA and DNA strands.
• Therapeutic Oligonucleotide Manufacturing: Critical raw material in the production of siRNA, antisense, and aptamer-based pharmaceuticals.
• Research & Diagnostic Probe Development: Used in academic and industrial labs to create labeled probes for genomics and molecular diagnostics.
• Process Development & Scale-Up: Supports process chemistry teams in optimizing and scaling oligonucleotide synthesis for clinical and commercial supply.
• GMP-Grade API Intermediate: Suitable as a starting material or intermediate in the manufacture of active pharmaceutical ingredients (APIs) under controlled GMP environments.

Basic Information

Product Name	N2-Isobutyryl-3',5'-o-(1,1,3,3-Tetraisopropyl-1,3-Disiloxanediyl)Guanosine
CAS No.	87865-78-9
Molecular Formula	C27H47N5O6Si2
Molecular Weight	593.87 g/mol
Synonyms	N2-Isobutyryl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)guanosine; Guanosine, N2-(2-methyl-1-oxopropoxy)-, 3',5'-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-; 3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)-N2-isobutyrylguanosine; TIPDS-protected N-Ibu-Guanosine; N-Ibu-Guanosine-3',5'-TIPDS ether; Protected Guanosine Phosphoramidite Precursor
EINECS	Contact for details

Quality Control

Every batch of N2-Isobutyryl-3',5'-o-(1,1,3,3-Tetraisopropyl-1,3-Disiloxanediyl)Guanosine is manufactured and tested under strict quality management systems. We guarantee high chemical purity and identity confirmed by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to ensure traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or in a controlled atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.