Description

Pam3-Cys-Ser-Ser-Asn-Ala-Oh is a synthetic lipopeptide derivative of bacterial lipoprotein, widely recognized as a potent toll-like receptor 2 (TLR2) agonist. This compound is essential for its robust immunostimulatory activity, making it a critical component in immunological research and adjuvant development. It is primarily utilized by pharmaceutical R&D teams and biotechnology companies focused on vaccine formulation, immunotherapy, and fundamental immunology studies to enhance immune responses.

Application

• Vaccine Adjuvant Research: A key component in preclinical studies for developing novel vaccine formulations to enhance antigen-specific immune responses.
• Immunology & Cell Signaling Studies: Used as a standard TLR2 ligand to stimulate innate immune cells (e.g., macrophages, dendritic cells) and study cytokine production and signaling pathways.
• Immunotherapy Development: Investigated for its potential to modulate the tumor microenvironment and boost anti-cancer immune activity in experimental therapies.
• Innate Immunity Research: Serves as a critical tool for understanding pattern recognition receptor (PRR) activation and downstream inflammatory cascades.
• Bioconjugation & Carrier Systems: Employed in the design of conjugate vaccines and nanoparticle-based delivery systems to improve immunogenicity.

Basic Information

Product Name	Pam3-Cys-Ser-Ser-Asn-Ala-Oh
CAS No.	87173-03-3
Molecular Formula	C33H60N8O11S
Molecular Weight	776.94 g/mol
Synonyms	Pam3Cys-SSNA; N-Palmitoyl-S-[2,3-bis(palmitoyloxy)propyl]-L-cysteinyl-L-seryl-L-seryl-L-asparaginyl-L-alanine; Pam3CSSNA; TLR2 Agonist Pam3CSK4 analog; S-[2,3-Bis(palmitoyloxy)propyl]-(R)-cysteinyl-seryl-seryl-asparaginyl-alanine; Tripalmitoyl-S-glyceryl cysteinylserinylserinylasparaginylalanine; Synthetic Lipopeptide TLR2 Ligand
EINECS	Contact for details

Quality Control

Our Pam3-Cys-Ser-Ser-Asn-Ala-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for research-grade biochemicals, ensuring reliable performance in sensitive immunological assays.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.