Description

U-62066 (Spiradoline Mesylate) is a potent and selective κ-opioid receptor (KOR) agonist, a key research compound for investigating pain pathways and central nervous system disorders. Its high selectivity makes it a critical tool for pharmacological studies targeting the κ-opioid system without significant activity at mu- or δ-opioid receptors. This compound is essential for researchers and developers in pharmaceutical R&D, neuropharmacology, and preclinical studies focused on analgesia, addiction, and mood regulation.

Application

• Neuroscience Research: A standard pharmacological tool for studying the role of κ-opioid receptors in pain modulation, stress response, and reward pathways.
• Analgesic Development: Used in preclinical models to investigate novel, non-addictive analgesic mechanisms and potential therapeutic candidates.
• Psychiatric Disorder Research: Applied in studies exploring the implications of the KOR system in depression, anxiety, and substance use disorders.
• Receptor Binding & Signal Transduction Assays: Serves as a reference standard in competitive binding studies and functional assays to characterize new compounds.
• Academic & Institutional Research: Fundamental for university and research institute labs conducting advanced neuropharmacology experiments.
• Biotech & Pharmaceutical R&D: Critical for drug discovery programs aimed at developing selective KOR agonists or antagonists for clinical applications.

Basic Information

Product Name	U-62066 (Spiradoline Mesylate) K-Opioid Agonist
CAS No.	87151-85-7
Molecular Formula	C19H28N2O2 • CH4O3S
Molecular Weight	420.55 g/mol
Synonyms	Spiradoline Mesylate; U-62066; U 62066; U62,066; (5α,7α,8β)-N-Methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-4-benzofuranacetamide methanesulfonate; 4-Benzofuranacetamide, N-methyl-N-[(5α,7α,8β)-7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-, monomethanesulfonate
EINECS	Contact for details

Quality Control

Our U-62066 (Spiradoline Mesylate) is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality standards for research chemicals, ensuring reliable performance in sensitive biological assays.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.