Description

Polyadenylic-Guanylic Acid Potassium is a synthetic, double-stranded polynucleotide complex composed of polyadenylic acid and polyguanylic acid, stabilized with potassium ions. This compound is a critical research-grade biochemical tool, valued for its ability to act as a potent immunostimulant and interferon inducer in biological systems. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and immunology sectors for vaccine adjuvant studies, antiviral research, and investigating innate immune response pathways.

Application

• Immunological Research: Used as a model immunostimulant and toll-like receptor (TLR) agonist to study innate immune activation and cytokine production.
• Vaccine Adjuvant Development: Investigated for its potential to enhance the efficacy of prophylactic and therapeutic vaccines by stimulating a robust immune response.
• Antiviral Studies: Employed in research to evaluate interferon-mediated antiviral activity and host defense mechanisms against viral infections.
• Cell Signaling Pathways: Serves as a tool to dissect intracellular signaling cascades triggered by nucleic acid-sensing receptors.
• Biochemical Reagent: Acts as a substrate or standard in enzymatic assays and molecular biology techniques involving polynucleotide interactions.
• Drug Delivery System Research: Explored as a component in novel nanoparticle or liposomal formulations designed for targeted immunomodulation.

Basic Information

Item	Detail
Product Name	Polyadenylic-Guanylic Acid Potassium
CAS No.	86828-73-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Poly(A)-Poly(G) Potassium Salt; Polyadenylic-Polyguanylic Acid Potassium Salt; Poly A:Poly G Potassium; Polyadenylate-Guanylate Potassium Complex; Poly rA:Poly rG K+ Salt; Polyriboadenylic-Polyriboguanylic Acid Potassium; TLR Agonist Poly A:U; Poly A/G Potassium
EINECS	Contact for details

Quality Control

Our Polyadenylic-Guanylic Acid Potassium is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. A Certificate of Analysis (COA) is provided, detailing key parameters such as polynucleotide length, duplex integrity, endotoxin levels, and bioburden, supporting its use in critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (UV-Vis)	Characteristic absorbance profile for polynucleotide duplex
Assay (HPLC)	≥ 95% (Polynucleotide content)
Duplex Integrity	Meets established criteria
Endotoxin	< 10 EU/mg
Bioburden	Meets in-house specifications
Solubility	Soluble in sterile water or buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.