Description

Polyadenylic-Uridylic Acid Potassium is a synthetic, double-stranded polynucleotide complex composed of polyadenylic acid and polyuridylic acid, stabilized as the potassium salt. This compound is a critical research-grade biochemical with significant biological activity, primarily serving as a potent inducer of interferon production. It is essential for researchers and developers in the fields of immunology, virology, and molecular biology, where it is used to study immune response mechanisms, antiviral defenses, and as a model for double-stranded RNA interactions.

Application

• Immunological Research: Used as a standard inducer of interferon (IFN) in cell culture studies to model innate immune responses.
• Virology Studies: Employed to investigate host antiviral defense pathways activated by double-stranded RNA (dsRNA) mimics.
• Pharmaceutical Development: Serves as a reference compound and tool in the preclinical screening and development of novel immunomodulators and antiviral agents.
• Molecular Biology: Acts as a model dsRNA structure for studying protein-RNA interactions, RNA stability, and enzymatic processes like those mediated by dicer and RIG-I-like receptors.
• Cell Signaling Pathways: Utilized to activate PKR (Protein Kinase R) and other dsRNA-sensing pathways to elucidate cellular stress and apoptosis mechanisms.
• Vaccine Adjuvant Research: Investigated for its potential immunostimulatory properties in experimental adjuvant formulations.

Basic Information

Product Name	Polyadenylic-Uridylic Acid Potassium
CAS No.	86828-72-0
Molecular Formula	(C10H12N5O7P • C9H11N2O9P)n • xK
Molecular Weight	Variable (Polymer)
Synonyms	Poly(A:U) Potassium Salt; Polyadenylic-Polyuridylic Acid Potassium Salt; Poly A:U; Poly rA:rU Potassium; Polyadenylic Acid - Polyuridylic Acid Complex Potassium; Poly A-U; dsRNA Poly(A:U); Potassium Polyadenylate-Polyuridylate
EINECS	Contact for details

Quality Control

Our Polyadenylic-Uridylic Acid Potassium is produced and tested to meet high-purity standards suitable for research applications. Each batch undergoes rigorous analytical testing to ensure identity, purity, and biological activity. A comprehensive Certificate of Analysis (COA) detailing specifications such as absorbance ratios (A260/A280), endotoxin levels, and biopotency (interferon induction assay) is provided to guarantee consistent quality and performance for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white fibrous solid or lyophilized powder
Identification (IR)	Conforms to reference spectrum
Identification (UV-Vis)	Characteristic absorbance profile with λmax ~260 nm
Absorbance Ratio (A260/A280)	1.8 - 2.0
Assay (HPLC)	≥ 95% (Polymer Content)
Biopotency	Induces interferon production in specified cell line assay (Contact for details)
Endotoxin	< 10 EU/mg
Solubility	Soluble in water and buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.