Description

Polycytidylic-Uridylic Acid Potassium is a synthetic, double-stranded RNA homopolymer complex, a potassium salt form of poly(C) and poly(U). This compound is a critical research-grade biochemical tool, valued for its ability to stimulate interferon production and mimic viral RNA structures. It is primarily utilized by biotechnology, pharmaceutical, and academic research institutions focused on immunology, antiviral research, and molecular biology studies.

Application

• Immunological Research: Used as a potent inducer of interferon for studying innate immune responses and cytokine signaling pathways.
• Antiviral Studies: Serves as a model for viral double-stranded RNA to investigate host-cell recognition mechanisms and evaluate potential antiviral compounds.
• Vaccine Adjuvant Development: Explored in preclinical research for its immunostimulatory properties to enhance vaccine efficacy.
• Cell Culture & In Vitro Diagnostics: Employed in cell-based assays to trigger specific immune responses and study gene expression under simulated viral infection.
• Biochemical Standard: Acts as a reference standard in chromatography and spectroscopic analysis for nucleic acid-related products.
• Pharmaceutical Intermediates: Potential use in the development of novel immunotherapeutics and nucleic acid-based drugs.

Basic Information

Product Name	Polycytidylic-Uridylic Acid Potassium
CAS No.	86828-71-9
Molecular Formula	(C9H11N3O8P • C9H12N2O8P)n • xK
Molecular Weight	Variable (Polymer)
Synonyms	Poly(C:U) Potassium Salt; Poly C-U Potassium Salt; Polycytidylic-Polyuridylic Acid Potassium Salt; Poly I:C Analog; dsRNA Polymer Potassium Salt; Poly r(C:U) • K; Potassium Polycytidylate-Polyuridylate; Poly(C,U)
EINECS	Contact for details

Quality Control

Our Polycytidylic-Uridylic Acid Potassium is manufactured under controlled conditions to ensure batch-to-batch consistency for research applications. Each lot undergoes rigorous analytical testing, including assessment of polymer length, strand integrity, and purity profile. A comprehensive Certificate of Analysis (COA) detailing specifications such as absorbance ratios (A260/A280), endotoxin levels, and bioburden is provided to guarantee it meets the stringent requirements for life science research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation. For long-term stability, store under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white fibrous solid or powder
Identification (UV-Vis)	Characteristic absorption spectrum for poly(C) and poly(U)
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95% (Polymer Content)
Absorbance Ratio (A260/A280)	1.8 - 2.0
pH (1% Solution)	6.0 - 8.0
Endotoxin	< 10 EU/mg
Bioburden	To specification

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.