Description

Polydeoxyadenylic-Thymidylic Acid Sodium Salt is a synthetic, double-stranded polynucleotide composed of alternating deoxyadenylic and thymidylic acid residues. This compound serves as a critical model system and reagent in molecular biology research for studying nucleic acid structure, protein-DNA interactions, and enzyme kinetics. It is essential for laboratories and R&D departments in the biotechnology, pharmaceutical, and academic sectors requiring high-purity synthetic DNA for diagnostic development and biochemical assays.

Application

• Molecular Biology Research: Used as a standard substrate or template for studying DNA polymerases, nucleases, and other DNA-modifying enzymes.
• Biochemical Assays: Serves as a model duplex DNA in binding studies for transcription factors, histones, and other DNA-binding proteins.
• Diagnostic Development: Acts as a control or calibrator in the development of nucleic acid-based diagnostic tests and kits.
• Biophysical Studies: Employed in spectroscopic analysis (e.g., UV, CD) to investigate DNA conformation, stability, and hybridization properties.
• Pharmaceutical R&D: Utilized in screening programs for novel therapeutics that target specific DNA sequences or structures.

Basic Information

Product Name	Polydeoxyadenylic-Thymidylic Acid Sodium Salt
CAS No.	86828-69-5
Molecular Formula	(C10H12N5O6P • C10H13N2O7P)n • xNa
Molecular Weight	Variable (Polymer)
Synonyms	Poly(dA-dT) Sodium Salt; Poly(deoxyadenylic-deoxythymidylic) Acid Sodium Salt; Poly(dA-dT); Poly(dA-dT) Sodium; Poly(dA-dT) duplex; Alternating dA-dT copolymer; Poly(deoxyadenylate-deoxythymidylate); DNA Polymer (dA-dT)
EINECS	Contact for details

Quality Control

Our Polydeoxyadenylic-Thymidylic Acid Sodium Salt is manufactured under controlled conditions to ensure batch-to-batch consistency for research applications. Each lot is characterized to confirm identity, purity, and structural integrity. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications such as absorbance ratios, melting temperature (Tm), and chain length assessment. We adhere to stringent in-house quality standards suitable for life science research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, desiccate at -20°C. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White or off-white fibrous solid
Identification (UV-Vis)	Characteristic absorbance profile
A260/A280 Ratio	1.8 - 2.0
Hypochromicity	> 25%
Melting Temperature (Tm)	Contact for details
Chain Length (Average)	Specified per grade (e.g., 500-2000 base pairs)
Solubility	Soluble in TE buffer or nuclease-free water
Endotoxin Level	< 0.1 EU/μg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.