Description

9-Deazaadenosine Triphosphate is a chemically modified nucleotide analog where a nitrogen atom in the adenine ring is replaced by a carbon atom, creating a stable, non-hydrolyzable ATP mimic. This structural modification is critical for its role as a potent and selective inhibitor of ATP-dependent enzymes, particularly kinases and helicases, in biochemical research. It is an essential tool for scientists in pharmaceutical R&D, molecular biology, and enzymology who require precise control over nucleotide-dependent signaling pathways.

Application

• Enzyme Inhibition Studies: Used as a competitive inhibitor to investigate the mechanism and kinetics of ATP-binding enzymes, including protein kinases, DNA/RNA helicases, and ATPases.
• Biochemical Assay Development: Serves as a stable, non-hydrolyzable substrate or inhibitor in high-throughput screening (HTS) assays for drug discovery.
• Structural Biology: Employed in X-ray crystallography and NMR studies to obtain co-crystal structures of enzyme-inhibitor complexes for rational drug design.
• Signal Transduction Research: A key reagent for studying ATP-mediated signaling cascades in cell biology, helping to elucidate disease mechanisms in oncology and neurology.
• Diagnostic Kit Manufacturing: Incorporated as a critical component in diagnostic assays and kits that detect specific enzymatic activities.

Basic Information

Product Name	9-Deazaadenosine Triphosphate
CAS No.	86568-55-0
Molecular Formula	C11H17N4O13P3
Molecular Weight	530.18 g/mol
Synonyms	9-Deaza-ATP; 9-Deazaadenosine 5'-triphosphate; 9-Carba-ATP; 1-Deazaadenosine triphosphate (positional isomer); Non-hydrolyzable ATP analog; ATP-γ-S competitive inhibitor; P1,P5-Di(adenosin-5'-yl) pentaphosphate analog; 9-Deaza-adenosine-5'-triphosphate
EINECS	Contact for details

Quality Control

Our 9-Deazaadenosine Triphosphate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. A detailed Certificate of Analysis (COA) documenting purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Biological Activity	Inhibits target kinase activity as specified
Endotoxin	< 1.0 EU/mg (for cell-based applications)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.