Description

Polymyxin B Nonapeptide Hydrochloride is a synthetic derivative of the polymyxin B antibiotic, specifically engineered to retain potent membrane-disrupting activity while reducing nephrotoxicity. This compound is a critical research tool and a key intermediate in the development of novel antimicrobial agents and endotoxin-neutralizing therapies. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and manufacturers in the biotechnology sector focusing on sepsis treatment, novel antibiotic discovery, and peptide-based drug delivery systems.

Application

• Antimicrobial Peptide Research: A fundamental tool for studying the structure-activity relationship of polymyxins and the mechanism of action against Gram-negative bacteria.
• Endotoxin (LPS) Neutralization Studies: Used in laboratory research to bind and neutralize bacterial lipopolysaccharides, crucial for sepsis and inflammation models.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel, less toxic polymyxin derivatives and next-generation antibiotics.
• Membrane Permeability Enhancer: Employed in research to increase cell membrane permeability, facilitating the uptake of other drugs or molecules.
• Biochemical Reagent: Used in in-vitro diagnostic assays and research kits designed to detect or quantify bacterial endotoxins.
• Drug Delivery System Development: Investigated for its potential in creating targeted delivery systems that exploit its membrane-interacting properties.

Basic Information

Product Name	Polymyxin B Nonapeptide Hydrochloride
CAS No.	86408-36-8
Molecular Formula	C56H100N16O13 • xHCl
Molecular Weight	~1204.4 (base)
Synonyms	PMBN; Polymyxin B Nonapeptide; N-Acetylpolymyxin B Nonapeptide Derivative; Polymyxin B Derivative; Endotoxin Neutralizing Peptide; LPS-binding Peptide; Antibacterial Peptide Fragment; PB-9
EINECS	Contact for details

Quality Control

Our Polymyxin B Nonapeptide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, MS for identity confirmation, and endotoxin level assessment to ensure it meets the exacting standards required for research and pharmaceutical development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95.0%
Assay (Anhydrous Basis)	≥90.0%
Water Content (KF)	≤5.0%
Endotoxin Level (LAL)	<10 EU/mg
Single Impurity (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.