Description

8-Oxoguanosine 2'-Phosphate is a modified nucleoside monophosphate of significant research interest. This compound serves as a critical biochemical tool for studying oxidative DNA damage and repair mechanisms. It is essential for researchers and manufacturers in the fields of nucleic acid chemistry, molecular biology diagnostics, and pharmaceutical development, particularly for investigating biomarkers of oxidative stress.

Application

• Biochemical Research: Used as a standard or substrate in studies of oxidative DNA/RNA damage, base excision repair (BER) pathways, and the role of 8-oxoguanine lesions in mutagenesis and disease.
• Diagnostic Assay Development: Employed in the research and development of enzymatic assays and kits designed to detect and quantify oxidative damage in nucleic acids.
• Enzymology Studies: Serves as a specific substrate for characterizing the activity of repair enzymes such as 8-oxoguanine DNA glycosylase (OGG1) and other nucleases or phosphatases.
• Pharmaceutical Screening: Utilized in high-throughput screening platforms to identify potential therapeutic compounds that modulate DNA repair activity.
• Reference Standard: Acts as a high-purity analytical standard for the calibration of instruments (HPLC, LC-MS) and validation of methods for detecting oxidized nucleotides in biological samples.
• Synthesis of Complex Probes: Can be used as a building block for the chemical or enzymatic synthesis of oligonucleotide probes containing site-specific oxidative lesions for advanced biophysical studies.

Basic Information

Product Name	8-Oxoguanosine 2'-Phosphate
CAS No.	85775-41-3
Molecular Formula	C10H14N5O9P
Molecular Weight	379.22 g/mol
Synonyms	8-Oxo-2'-deoxyguanosine 2'-monophosphate; 8-Oxo-dGMP; 8-Hydroxy-2'-deoxyguanosine 2'-phosphate; 8-Oxo-2'-dGMP; 8-Oxo-2'-deoxyguanosine 5'-monophosphate (common misnomer, clarify position); 8-Oxoguanine deoxyribonucleoside 2'-monophosphate; 8-Oxo-7,8-dihydro-2'-deoxyguanosine 2'-phosphate; 2'-dGMP-8-oxo
EINECS	Contact for details

Quality Control

Our 8-Oxoguanosine 2'-Phosphate is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including purity assay and identity confirmation. A Certificate of Analysis (COA) detailing specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.