Description

(+)-α-Methoxy-α-(Trifluoromethyl)Phenylacetic Anhydride CAS NO 85541-57-7 is a high-purity chiral derivatizing agent and a key synthetic intermediate. Its primary value lies in its ability to resolve enantiomers of chiral amines and alcohols, making it indispensable for analytical and preparative-scale chiral separations. This compound is critically needed by pharmaceutical R&D laboratories, analytical service providers, and fine chemical manufacturers focused on producing enantiomerically pure active pharmaceutical ingredients (APIs).

Application

• Chiral Derivatization for HPLC Analysis: Used to prepare diastereomeric derivatives of racemic amines and alcohols for separation and quantification by standard reverse-phase HPLC.
• Enantiomeric Purity Determination: Essential for assessing the enantiomeric excess (ee) of chiral synthetic intermediates and final drug substances.
• Preparative Chiral Resolution: Employed in the synthesis of Mosher's acid chloride analogs for the large-scale separation of enantiomers.
• Pharmaceutical Intermediate: Serves as a building block in the synthesis of complex, stereochemically defined molecules.
• NMR Chiral Shift Reagent: Can be used to create diastereomers for analysis by 19F or 1H NMR spectroscopy.
• Reference Standard: Provides a high-purity benchmark for method development and validation in chiral analysis.

Basic Information

Product Name	(+)-α-Methoxy-α-(Trifluoromethyl)Phenylacetic Anhydride
CAS No.	85541-57-7
Molecular Formula	C20H16F6O5
Molecular Weight	450.33 g/mol
Synonyms	(R)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetic anhydride; (R)-Mosher's Acid Anhydride; (R)-MTPA Anhydride; (R)-(+)-Methoxy(trifluoromethyl)phenylacetic anhydride; Anhydride of (R)-(+)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid; (R)-O-Methylmandelic acid trifluoromethyl anhydride; (R)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid anhydride
EINECS	Contact for details

Quality Control

Our (+)-α-Methoxy-α-(Trifluoromethyl)Phenylacetic Anhydride is manufactured under strict quality control protocols to ensure high chemical and enantiomeric purity suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, enantiomeric excess, and impurity profile. We adhere to cGMP principles for pharmaceutical intermediates, and specifications can be aligned with customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.