Description

Trifluoroacetic Anhydride (CAS NO 407-25-0) is a highly reactive acylating and trifluoromethylating agent essential for introducing the trifluoroacetyl group into target molecules. Its primary value lies in its powerful reactivity, which is critical for synthesizing complex fluorinated compounds with enhanced stability and bioavailability. This chemical is indispensable for research and production in the pharmaceutical, agrochemical, and advanced materials sectors, where precise fluorination is required.

Application

• Pharmaceutical Synthesis: Key reagent for the production of active pharmaceutical ingredients (APIs), particularly in the synthesis of peptides and as a protecting group for amines and alcohols.
• Agrochemical Manufacturing: Used in the synthesis of advanced herbicides, pesticides, and fungicides that benefit from the metabolic stability imparted by fluorine atoms.
• Peptide Chemistry: Serves as a coupling agent and for the introduction of the trifluoroacetyl (TFA) protecting group, which is readily cleaved under mild conditions.
• Organic Synthesis & Catalysis: Acts as a potent catalyst and solvent in various organic transformations, including Friedel-Crafts acylations and esterifications.
• Polymer & Material Science: Employed in the surface modification of polymers and the synthesis of fluorinated monomers for high-performance materials.
• Analytical Chemistry: Used as a derivatization agent in gas chromatography and mass spectrometry to improve the volatility and detection of analytes.

Basic Information

Item	Detail
Product Name	Trifluoroacetic Anhydride
CAS No.	407-25-0
Molecular Formula	C4F6O3
Molecular Weight	210.03 g/mol
Synonyms	TFAA; Trifluoroacetic Acid Anhydride; Perfluoropropionic Anhydride; 2,2,2-Trifluoroacetic Anhydride; Acetic Acid, Trifluoro-, Anhydride; Bis(trifluoroacetic) Anhydride; Anhydride Trifluoroacétique (French); Trifluoressigsäureanhydrid (German)
EINECS	206-982-9

Quality Control

Our Trifluoroacetic Anhydride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and a strong acid/organic solvent; it must be kept away from moisture, bases, and oxidizing agents. Use appropriate corrosion-resistant storage materials.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms
Assay (GC)	≥ 99.0%
Water Content (Karl Fischer)	≤ 0.05%
Refractive Index (n20D)	1.268 - 1.272
Density (20°C)	1.487 - 1.497 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.