Description

Di-tert-Butyl Dicarbonate is a highly versatile and essential reagent in organic synthesis, primarily used as a protecting agent for amines. Its core value lies in its ability to introduce the tert-butoxycarbonyl (Boc) protecting group, which is crucial for the synthesis of peptides, pharmaceuticals, and fine chemicals. This compound is indispensable for research and production chemists in the pharmaceutical, biotechnology, and agrochemical industries who require reliable and high-purity intermediates for complex molecule assembly.

Application

• Boc-Protection of Amines: The primary application for the selective protection of primary and secondary amines in peptide and pharmaceutical synthesis.
• Pharmaceutical Intermediate: A key building block in the manufacture of active pharmaceutical ingredients (APIs), including various antibiotics and antivirals.
• Peptide Synthesis: Widely used in solid-phase and solution-phase peptide synthesis to protect amino acids during chain elongation.
• Organic Synthesis Reagent: Employed in the synthesis of complex natural products, heterocycles, and other fine chemicals requiring temporary amine protection.
• Agrochemical Production: Used in the development and manufacturing of certain herbicides and pesticides where amine functionality needs to be masked.
• Bioconjugation Chemistry: Useful in modifying biomolecules for research, diagnostics, and therapeutic applications.

Basic Information

Product Name	Di-tert-Butyl Dicarbonate
CAS No.	24424-99-5
Molecular Formula	C10H18O5
Molecular Weight	218.25 g/mol
Synonyms	Boc Anhydride; Di-tert-butyl pyrocarbonate; (Boc)2O; Di-tert-butyl dicarbonate; tert-Butoxycarbonyl anhydride; Dicarbonic acid, bis(1,1-dimethylethyl) ester; DTBDC; BOC-ON (related reagent)
EINECS	246-240-1

Quality Control

Our Di-tert-Butyl Dicarbonate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC/GC assay and impurity profiling, to meet the stringent requirements of pharmaceutical and research applications. A Certificate of Analysis (COA) detailing purity, identity, and specific tests is available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (HPLC/GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.