Description

n-Carboxyvaline Anhydride (NCA) is a high-purity, reactive amino acid derivative essential for controlled polymer synthesis. This compound serves as a critical monomer for producing well-defined polypeptides and polyamino acids with specific chain lengths and architectures. It is primarily utilized by researchers and manufacturers in pharmaceutical development, biomaterials engineering, and advanced polymer science who require precise and reproducible building blocks.

Application

• Pharmaceutical Intermediates: Key monomer for the synthesis of polypeptide-based drug candidates, including antimicrobial peptides and drug delivery systems.
• Biomaterials Fabrication: Production of biodegradable and biocompatible polyamino acid scaffolds for tissue engineering and medical implants.
• Controlled Polymerization: Enables ring-opening polymerization (ROP) to create polymers with controlled molecular weight and low polydispersity for research and specialty applications.
• Surface Modification: Used to graft functional peptide chains onto surfaces to alter biocompatibility and interaction properties.
• Conjugate Chemistry: Acts as a versatile building block for creating peptide-polymer conjugates and hybrid materials.
• Academic & Industrial R&D: Fundamental reagent for studying polymerization mechanisms and developing new polymeric materials.

Basic Information

Product Name	n-Carboxyvaline Anhydride
CAS No.	1676-85-3
Molecular Formula	C6H9NO3
Molecular Weight	143.14 g/mol
Synonyms	L-Valine N-Carboxyanhydride; Valine NCA; NCA-Val; 2,5-Oxazolidinedione, 4-(1-methylethyl)-, (4S)-; (S)-4-Isopropyl-2,5-oxazolidinedione; L-Valine-N-carboxylic acid anhydride; α-Amino acid N-carboxyanhydride of L-valine; V-NCA
EINECS	Contact for details

Quality Control

Our n-Carboxyvaline Anhydride is manufactured under controlled conditions to ensure high reactivity and purity, critical for sensitive polymerization processes. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent internal quality standards to guarantee batch-to-batch consistency and reliability for your research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its moisture-sensitive and potentially oxygen-sensitive nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in polar aprotic solvents (e.g., DMF, DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.