Description

Boc-L-Alanine-Nca is a specialized N-carboxyanhydride (NCA) derivative of the amino acid L-alanine, protected with a tert-butoxycarbonyl (Boc) group. This compound is a critical building block in the synthesis of well-defined polypeptides and polymers via ring-opening polymerization (ROP), offering precise control over molecular weight and sequence. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for developing drug delivery systems, biodegradable polymers, and functional biomaterials. Its high reactivity and the orthogonality of the Boc protecting group make it an essential reagent for controlled peptide synthesis.

Application

• Controlled Peptide Synthesis: As a key monomer for the ring-opening polymerization (ROP) to produce poly(L-alanine) and alanine-based block copolymers with precise architectures.
• Biomedical Research: For creating model polypeptides to study protein folding, self-assembly, and biomimetic materials.
• Drug Delivery Systems: Synthesis of biodegradable polymeric carriers for controlled release of active pharmaceutical ingredients (APIs).
• Tissue Engineering Scaffolds: Fabrication of biocompatible and biodegradable matrices that support cell growth and tissue regeneration.
• Advanced Material Science: Development of functional polymers with specific mechanical or chemical properties for specialty coatings and films.
• Combinatorial Chemistry: Used in high-throughput synthesis for generating diverse peptide libraries for screening and discovery.

Basic Information

Product Name	Boc-L-Alanine-Nca
CAS No.	125814-30-4
Molecular Formula	C₉H₁₃NO₅
Molecular Weight	215.20 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-alanine N-carboxyanhydride; Boc-L-Ala-NCA; (S)-4-((tert-Butoxycarbonyl)amino)-2,5-dioxooxazolidine; Boc-L-Alanine N-Carboxyanhydride; N-Boc-L-alanine anhydride; Nα-Boc-L-alanine NCA; 1-(tert-Butoxycarbonylamino)ethyl 2,5-dioxooxazolidine-4-carboxylate
EINECS	Contact for details

Quality Control

Every batch of Boc-L-Alanine-Nca undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. Our quality assurance protocol includes advanced chromatographic and spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent hydrolysis and maintain reactivity. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in THF, DMF, DMSO; sparingly soluble in diethyl ether

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.