Description

Fmoc-Ala-N-Carboxyanhydride is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, enabling the controlled and efficient incorporation of alanine residues while protecting the α-amino group with the acid-labile Fmoc group. It is primarily required by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in the production of therapeutic peptides, peptidomimetics, and biochemical research reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key monomer for the sequential addition of alanine in Fmoc-based peptide chain assembly.
• Pharmaceutical R&D: For the synthesis of novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Bioconjugation: Used to introduce alanine residues into modified peptides, proteins, or other biomolecules.
• Combinatorial Chemistry: A vital component in libraries for high-throughput screening of bioactive peptides.
• Academic Research: Fundamental studies in peptide chemistry, structure-activity relationships (SAR), and molecular biology.
• Production of Custom Peptides: By CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects.

Basic Information

Product Name	Fmoc-Ala-N-Carboxyanhydride
CAS No.	125814-20-2
Molecular Formula	C19H15NO5
Molecular Weight	337.33 g/mol
Synonyms	Fmoc-Ala-NCA; N-(9-Fluorenylmethoxycarbonyl)-L-alanine N-carboxyanhydride; Fmoc-L-alanine NCA; (4S)-4-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,5-oxazolidinedione; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-alanine N-carboxyanhydride; Nα-Fmoc-L-alanine N-carboxyanhydride; Fmoc-L-alanine N-carboxylic Anhydride; Fmoc-protected alanine NCA
EINECS	Contact for details

Quality Control

Our Fmoc-Ala-N-Carboxyanhydride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and KF titration for moisture content. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -20.0° (c=1, DMF)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.