Description

Acetic Anhydride-D6 is a deuterated isotopologue of acetic anhydride, where all six hydrogen atoms are replaced by deuterium. This high-purity labeled compound is essential for applications requiring minimal interference from proton signals, such as advanced NMR spectroscopy and reaction mechanism studies. It is a critical reagent for researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry sectors who require precise isotopic labeling for metabolic studies, tracer analysis, and the synthesis of deuterated active pharmaceutical ingredients (APIs).

Application

• NMR Spectroscopy: Used as an internal standard, solvent, or derivatization agent in Nuclear Magnetic Resonance (NMR) to eliminate proton signal interference and simplify spectra.
• Pharmaceutical Research: A key precursor in the synthesis of deuterium-labeled drug molecules for pharmacokinetic, metabolic stability, and tracer studies.
• Mechanistic Studies: Employed in reaction mechanism elucidation and kinetic isotope effect (KIE) experiments in academic and industrial R&D.
• Mass Spectrometry: Serves as a derivatizing agent or standard in LC-MS and GC-MS for improved detection and quantification.
• Deuterated Material Synthesis: Used in the production of various deuterated fine chemicals, polymers, and advanced materials.
• Agrochemical Development: Utilized in creating labeled versions of pesticides and herbicides for environmental fate and metabolism studies.

Basic Information

Product Name	Acetic Anhydride-D6
CAS No.	16649-49-3
Molecular Formula	C4D6O3
Molecular Weight	114.12 g/mol
Synonyms	Acetic-d6 Anhydride; Perdeuteroacetic Anhydride; Deuterated Acetic Anhydride; Acetic Acid-d6 Anhydride; (CD3CO)2O; Hexadeuteroacetic Anhydride; Acetyl-d3 Anhydride-d3; Ethanoic-d6 Anhydride
EINECS	Contact for details

Quality Control

Our Acetic Anhydride-D6 is manufactured under controlled conditions to ensure exceptional isotopic and chemical purity. Each batch undergoes rigorous analysis, including NMR for deuterium enrichment and GC/HPLC for chemical purity and impurity profiling. A comprehensive Certificate of Analysis (COA) detailing isotopic purity (atom % D), chemical assay, and specific tests is provided with every shipment to guarantee consistency and reliability for your sensitive applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and highly volatile; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and moisture absorption. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms to structure
Isotopic Purity (Atom % D)	≥ 99.0% (by 1H NMR)
Chemical Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Acetic Acid-d4 (GC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.