Description

Nalpha-9-Fluorenylmethoxycarbonyl-L-Leucine n-Carboxylic Anhydride is a high-purity, activated amino acid derivative specifically designed for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the efficient and controlled elongation of peptide chains, enabling the production of complex peptides and proteins. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require reliable, high-quality reagents for advanced peptide chemistry and drug development.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid anhydride for automated and manual peptide assembly.
• Pharmaceutical Intermediate: In the research and development of novel therapeutic peptides, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation: For the site-specific modification of proteins, antibodies, and other biomolecules to create conjugates for drug delivery or diagnostics.
• Combinatorial Chemistry: Used in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Academic & Industrial Research: A fundamental reagent in biochemistry and organic chemistry laboratories for studying protein structure and function.
• Production of Custom Peptides: By contract research and manufacturing organizations (CROs/CMOs) for client-specific projects.

Basic Information

Product Name	Nalpha-9-Fluorenylmethoxycarbonyl-L-Leucine n-Carboxylic Anhydride
CAS No.	125814-21-3
Molecular Formula	C22H21NO5
Molecular Weight	379.41 g/mol
Synonyms	Fmoc-Leu-OH Anhydride; Fmoc-L-Leucine Anhydride; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucine Anhydride; Fmoc-Leucine N-Carboxyanhydride; Fmoc-Leu NCA; (9-Fluorenylmethyloxycarbonyl)-L-leucine anhydride; Nα-Fmoc-L-leucine anhydride; L-Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, anhydride
EINECS	Contact for details

Quality Control

Our Nalpha-9-Fluorenylmethoxycarbonyl-L-Leucine n-Carboxylic Anhydride is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity suitable for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing specifications such as purity (by HPLC), optical rotation, and moisture content. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive); containers must be sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]D20	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.