Description

2'-Deoxyguanosine-3'-(Phospho-2''-o-Glycolic Acid) is a chemically modified nucleoside derivative of significant importance in advanced pharmaceutical and biochemical research. This compound serves as a critical building block and intermediate in the synthesis of oligonucleotides, particularly for therapeutic applications such as antisense and siRNA technologies. It is essential for researchers and manufacturers in the fields of nucleic acid chemistry, drug discovery, and diagnostic development who require high-purity, specialized monomers for creating next-generation biotherapeutics.

Application

• Oligonucleotide Synthesis: A key phosphoramidite monomer for the solid-phase synthesis of therapeutic antisense oligonucleotides and siRNA.
• Pharmaceutical Intermediates: Serves as a crucial building block in the development of novel nucleotide-based drugs and prodrugs.
• Biochemical Research: Used in studies investigating DNA/RNA structure, function, and enzyme interactions.
• Diagnostic Probe Development: Employed in the creation of labeled probes for genetic testing and molecular diagnostics.
• Apitamer Construction: A component in the synthesis of modified aptamers with enhanced stability and binding affinity.

Basic Information

Item	Details
Product Name	2'-Deoxyguanosine-3'-(Phospho-2''-o-Glycolic Acid)
CAS No.	84881-71-0
Molecular Formula	C₁₂H₁₆N₅O₉P
Molecular Weight	405.26 g/mol
Synonyms	2'-Deoxyguanosine 3'-(2-O-Glycolic Acid) Phosphate; dG-3'-Glycolic Acid Phosphoramidite Precursor; 3'-O-[(2-Glycoloyl)phosphoryl]-2'-deoxyguanosine; Deoxyguanosine Glycolic Acid Ester Phosphate; 2'-Deoxyguanosine-3'-monophosphate glycolic acid ester; dG-3'-Glycolate Phosphate; 84881-71-0; Guanosine derivative, 2'-deoxy-3'-(phospho-2''-O-glycolic acid)
EINECS	Contact for details

Quality Control

Our 2'-Deoxyguanosine-3'-(Phospho-2''-o-Glycolic Acid) is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive pharmaceutical and research applications. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to verify identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support compliance with relevant regulatory frameworks for advanced therapeutic intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 3.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.