Description

Deoxy(Thymidylyl-Cytidylyl-Guanylyl-Adenylic Acid) is a defined-sequence tetranucleotide, a short fragment of single-stranded DNA. This high-purity synthetic oligonucleotide is critical for molecular biology research and diagnostic development, serving as a precise tool for hybridization, primer extension, and probe design. It is essential for researchers and manufacturers in the fields of genomics, molecular diagnostics, and pharmaceutical development who require sequence-specific nucleic acid components.

Application

• Molecular Biology Research: Used as a primer, probe, or template in PCR, sequencing, and cloning experiments.
• Diagnostic Assay Development: Serves as a key component in the design of hybridization-based tests for pathogen detection or genetic screening.
• Biochemical Studies: Employed in studies of DNA-protein interactions, enzyme kinetics (e.g., with polymerases or nucleases), and nucleic acid structure.
• Synthetic Biology: Acts as a building block for the assembly of longer synthetic genes or genetic circuits.
• Quality Control Standard: Used as a reference material in the validation and calibration of analytical methods for oligonucleotide synthesis and purification.

Basic Information

Product Name	Deoxy(Thymidylyl-Cytidylyl-Guanylyl-Adenylic Acid)
CAS No.	84520-45-6
Molecular Formula	C39H48N15O23P3
Molecular Weight	1187.80 g/mol
Synonyms	d(TpCpGpA); Tetranucleotide d(T-C-G-A); Thymidylyl-(3'→5')-cytidylyl-(3'→5')-guanylyl-(3'→5')-adenylic acid; Deoxytetranucleotide T-C-G-A; DNA tetramer TCGA; Oligodeoxyribonucleotide d(TCGA); Sequence-specific DNA fragment
EINECS	Contact for details

Quality Control

Our oligonucleotides are produced under controlled conditions and undergo rigorous analytical testing to ensure sequence integrity and purity. Each batch is characterized by HPLC for purity assessment and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing the assay, purity profile, and endotoxin levels are provided to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Assay (UV)	≥ 85%
Extinction Coefficient	Provided on COA
Molecular Weight	1187.80 g/mol (Theoretical)
Water Content (KF)	≤ 5.0%
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.