Description

3,5-Difluoro-2-Hydroxy-Benzoic Acid is a fluorinated derivative of salicylic acid, serving as a versatile and high-value organic building block. Its molecular structure, featuring both a carboxylic acid and a phenolic hydroxyl group with strategic fluorine substitutions, makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs). This compound is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where precise fluorination is required to modulate biological activity, stability, and physicochemical properties.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in fluorinated COX-2 inhibitors, kinase inhibitors, and other targeted therapeutics where fluorine atoms enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Building block for developing advanced herbicides, fungicides, and pesticides, leveraging fluorine's ability to increase lipophilicity and membrane permeability in active ingredients.
• Liquid Crystal & OLED Materials: Used in the production of fluorinated aromatic cores for electronic display materials, improving thermal stability, optical properties, and charge transport characteristics.
• Polymer & Resin Modifier: Incorporates into specialty polymers to impart enhanced chemical resistance, thermal stability, and unique surface properties.
• Complex Ligand & Chelator: Serves as a starting material for synthesizing fluorinated ligands used in catalysis and metal-organic frameworks (MOFs).
• Research & Development: A valuable reagent in academic and industrial R&D for exploring structure-activity relationships (SAR) and developing new fluorination methodologies.

Basic Information

Product Name	3,5-Difluoro-2-Hydroxy-Benzoic Acid
CAS No.	84376-20-5
Molecular Formula	C7H4F2O3
Molecular Weight	174.10 g/mol
Synonyms	2-Hydroxy-3,5-difluorobenzoic Acid; 3,5-Difluorosalicylic Acid; Benzoic acid, 3,5-difluoro-2-hydroxy-; 3,5-Difluoro-2-hydroxybenzoic acid; 3,5-Difluoro-2-hydroxy-benzoic acid; 3,5-Difluoro-2-hydroxybenzoic acid; 3,5-Difluoro-2-hydroxybenzoic acid (DFHBA)
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-2-Hydroxy-Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your specific R&D or cGMP requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.