Description

3,5-Difluorocinnamic Acid is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of pharmaceuticals, agrochemicals, and functional materials, where its difluorophenyl moiety imparts desirable metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and pesticides, leveraging fluorine's bioactivity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated organic semiconductors and liquid crystal compounds for electronic displays.
• Peptide Mimetics & Bioconjugation: The carboxylic acid group enables its use in creating fluorinated amino acid analogs or as a linker in bioconjugation chemistry.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to introduce the difluorophenyl group.
• Chemical Research & Development: A versatile reagent in academic and industrial labs for exploring new fluorination strategies and structure-activity relationships.

Basic Information

Product Name	3,5-Difluorocinnamic Acid
CAS No.	84315-23-1
Molecular Formula	C9H6F2O2
Molecular Weight	184.14 g/mol
Synonyms	(E)-3-(3,5-Difluorophenyl)acrylic acid; 3,5-Difluorocinnamate; trans-3,5-Difluorocinnamic Acid; 3-(3,5-Difluorophenyl)-2-propenoic acid; 3,5-Difluorobenzeneacrylic acid; 2-Propenoic acid, 3-(3,5-difluorophenyl)-, (2E)-; 3,5-DFCA
EINECS	Contact for details

Quality Control

Our 3,5-Difluorocinnamic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor quality protocols to meet specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizers, strong bases, and heat sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Melting Point	185°C - 190°C
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.