Description

(S)-(+)-2-Methylbutyric Anhydride is a high-purity, chiral anhydride derivative of 2-methylbutyric acid. This compound is a critical chiral building block and acylating agent, valued for its ability to introduce the (S)-2-methylbutyryl moiety with high stereochemical fidelity. It is primarily sought after by research and development laboratories, as well as production facilities, in the pharmaceutical, agrochemical, and specialty fragrance industries for the synthesis of enantiomerically pure active ingredients and flavor compounds.

Application

• Pharmaceutical Intermediate: Key chiral precursor for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in stereoselective acylation reactions.
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides where specific stereochemistry is required for biological activity.
• Flavor & Fragrance Industry: Employed as a building block for creating natural-tasting chiral esters and lactones that contribute to complex flavor and aroma profiles.
• Asymmetric Synthesis: Serves as a versatile chiral acylating agent in organic synthesis for the resolution of racemic mixtures or the introduction of chiral centers.
• Biochemical Research: Utilized in proteomics and peptide chemistry for selective modification of amino groups under mild conditions.
• Polymer Chemistry: Can be used as a monomer or modifying agent for introducing chiral side chains into specialty polymers.

Basic Information

Product Name	(S)-(+)-2-Methylbutyric Anhydride
CAS No.	84131-91-9
Molecular Formula	C10H18O3
Molecular Weight	186.25 g/mol
Synonyms	(S)-(+)-2-Methylbutanoic Anhydride; (S)-2-Methylbutyric Anhydride; (S)-2-Methylbutanoic Acid Anhydride; L-2-Methylbutyric Anhydride; (S)-2-Methyl-1-butanecarboxylic Acid Anhydride; (S)-α-Methylbutyric Anhydride; (S)-Active Amyl Anhydride; (S)-(+)-2-Methylbutyryl Oxide
EINECS	Contact for details

Quality Control

Our (S)-(+)-2-Methylbutyric Anhydride is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by chiral GC or HPLC, to ensure high enantiomeric excess (typically >98% ee) and chemical purity. Certificates of Analysis (COA) detailing identity, assay, specific rotation, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent hydrolysis. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Specific Rotation [α]	+15° to +20° (c=1, CHCl3)
Assay (GC)	≥ 97.0%
Enantiomeric Excess (Chiral GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.