Description

2H-1,2,4-Benzothiadiazine-7-Sulfonamide, 3,4-Dihydro-6-Hydroxy-, 1,1-Dioxide is a high-purity sulfonamide derivative and a key advanced pharmaceutical intermediate. This compound is valued for its precise chemical structure, which is critical for the synthesis of active pharmaceutical ingredients (APIs) with specific therapeutic effects. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and production of novel diuretic and antihypertensive agents.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of thiazide-like diuretics and related antihypertensive drugs.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for new cardiovascular medications.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development and quality control in pharmaceutical labs.
• Biochemical Research: Employed in studies investigating carbonic anhydrase inhibition and renal physiology.
• Process Chemistry: Utilized in scale-up and optimization of synthetic routes for complex sulfonamide-based molecules.

Basic Information

Product Name	2H-1,2,4-Benzothiadiazine-7-Sulfonamide, 3,4-Dihydro-6-Hydroxy-, 1,1-Dioxide
CAS No.	82205-98-9
Molecular Formula	C7H7N3O5S2
Molecular Weight	277.28 g/mol
Synonyms	6-Hydroxy-3,4-dihydro-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-Hydroxy-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide; Hydroflumethiazide Impurity; Hydroflumethiazide Related Compound; 7-Sulfamoyl-6-hydroxy-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide; 3,4-Dihydro-6-hydroxy-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
EINECS	Contact for details

Quality Control

Our 2H-1,2,4-Benzothiadiazine-7-Sulfonamide, 3,4-Dihydro-6-Hydroxy-, 1,1-Dioxide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.