Description

Mesulergine Hydrochloride CAS NO 81855-34-7 is a high-purity chemical compound belonging to the ergoline class, primarily utilized as a potent and selective serotonin receptor antagonist in advanced research. Its significance lies in its critical role as a reference standard and active pharmaceutical ingredient (API) intermediate for neurological and pharmacological studies. This product is essential for pharmaceutical R&D laboratories, academic institutions, and biotechnology companies focused on developing and testing novel therapeutic agents targeting the central nervous system.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of new drugs targeting serotonin (5-HT) receptors.
• Neuroscience Studies: Used as a selective pharmacological tool to investigate serotonin receptor subtypes and their functions in the brain.
• Biochemical Assay Development: Employed as a standard compound in high-throughput screening (HTS) and receptor binding assays.
• Academic Research: Utilized in university and institutional labs for fundamental studies in neurochemistry and psychopharmacology.
• API Manufacturing: Acts as a critical building block in the controlled, multi-step synthesis of complex pharmaceutical actives.
• Quality Control & Analytical Testing: Functions as a certified reference material (CRM) for method validation and impurity profiling in QC laboratories.

Basic Information

Product Name	Mesulergine Hydrochloride
CAS No.	81855-34-7
Molecular Formula	C₂₀H₂₆ClN₃O₂
Molecular Weight	375.89 g/mol
Synonyms	Mesulergine HCl; 1-[(8β)-6-Methylergolin-8-yl]-3-(methylamino)propan-1-one hydrochloride; CU 32-085; Methergoline analog; 5-HT2C receptor antagonist; Serotonin antagonist
EINECS	Contact for details

Quality Control

Our Mesulergine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and stringent control of residual solvents and related substances. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports your need for reliable and consistent material in sensitive applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.