Description

3-Methylpseudouridine is a chemically modified nucleoside analog of uridine, playing a pivotal role in the advancement of mRNA-based therapeutics and vaccines. Its incorporation into mRNA sequences significantly enhances stability and translational efficiency while reducing immunogenicity, which is critical for developing effective and safe biological products. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors focused on next-generation drug development.

Application

• mRNA Vaccine & Therapeutic Production: A critical raw material for synthesizing modified mRNA to improve protein expression and stability.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Biochemical Research: Used in studies investigating RNA structure, function, and the mechanisms of translation.
• Therapeutic Oligonucleotide Synthesis: Employed in the manufacture of siRNA, antisense oligonucleotides, and other RNA therapeutics requiring enhanced nuclease resistance.
• Diagnostic Probe Development: Utilized in creating stable, high-affinity probes for nucleic acid detection and diagnostics.

Basic Information

Product Name	3-Methylpseudouridine
CAS No.	81691-06-7
Molecular Formula	C10H14N2O6
Molecular Weight	258.23 g/mol
Synonyms	3-Methyl-β-pseudouridine; 3-Methyl-5-ribosyluracil; N3-Methylpseudouridine; m3ψ; 3-Methyl-ψ; 3-Methyl-5-(β-D-ribofuranosyl)uracil; 1-Methyl-1H-pyrimidine-2,4-dione, 5-(β-D-ribofuranosyl)-
EINECS	Contact for details

Quality Control

Our 3-Methylpseudouridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for pharmaceutical and research applications. Certificates of Analysis (COA) are provided and specifications can be aligned with current Good Manufacturing Practice (cGMP) standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under inert atmosphere or desiccant when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.