Description

Levlofexidine CAS NO 81447-78-1 is a high-purity pharmaceutical intermediate and active ingredient belonging to the class of α-2 adrenergic receptor agonists. This compound is critical for its role in the synthesis and formulation of advanced therapeutic agents targeting specific neurological and cardiovascular pathways. It is primarily required by pharmaceutical manufacturers and advanced research institutions engaged in drug discovery and development.

Application

• Key intermediate in the synthesis of pharmaceutical active ingredients (APIs) with α-2 adrenergic activity.
• Research and development of novel therapeutics for hypertension and cardiovascular conditions.
• Preclinical and clinical studies investigating agents for opioid withdrawal symptom management.
• Production of reference standards and analytical controls for quality assurance in pharmaceutical manufacturing.
• Development of specialized formulations in controlled-release drug delivery systems.
• Chemical synthesis for creating derivatives with modified pharmacological profiles.

Basic Information

Product Name	Levlofexidine
CAS No.	81447-78-1
Molecular Formula	C11H13ClN2
Molecular Weight	208.69 g/mol
Synonyms	Lofexidine, (R)-Lofexidine, (-)-Lofexidine, 2-[1-(2,6-Dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole, BritLofex, Lu AA27122
EINECS	Contact for details

Quality Control

Our Levlofexidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.