Description

n-(3-(Dimethylamino)Propyl)-n-((Ethylamino)Carbonyl)-6-n-Propylergolin E-8-β-Carboxamide CAS NO 81409-92-9 is a complex ergoline derivative, a class of compounds known for their significant biological activity and structural complexity. This high-purity intermediate is critical for advanced pharmaceutical research and development, particularly in the synthesis of specialized active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics targeting neurological and cardiovascular systems.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of novel ergot alkaloid-derived APIs.
• Neurological Research: Used in preclinical studies for developing potential treatments for conditions like migraines, Parkinson's disease, and hyperprolactinemia.
• Cardiovascular Agent Development: Investigated for its potential vasoactive properties in the creation of new cardiovascular medications.
• Biochemical Tool Compound: Employed in receptor binding assays and pharmacological studies to understand serotonin and dopamine receptor interactions.
• Process Chemistry & Scale-Up: Utilized in process optimization and scale-up activities from laboratory to pilot plant scale for new drug candidates.
• Reference Standard: Acts as a high-purity analytical reference standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	n-(3-(Dimethylamino)Propyl)-n-((Ethylamino)Carbonyl)-6-n-Propylergolin E-8-β-Carboxamide
CAS No.	81409-92-9
Molecular Formula	C25H39N5O2
Molecular Weight	441.61 g/mol
Synonyms	6-n-Propyl-8β-[[[N-ethylamino]carbonyl]amino]methyl]-1,6-dimethylergoline-8-methanol; 6-n-Propyl-8β-carbamoylergoline derivative; Pergolide related compound B; Pergolide Impurity B; U-58,073; (8β)-N-[(Ethylamino)carbonyl]-6-propylergoline-8-carboxamide; 6-n-Propyl-8β-carboxamidoergoline
EINECS	Contact for details

Quality Control

Our n-(3-(Dimethylamino)Propyl)-n-((Ethylamino)Carbonyl)-6-n-Propylergolin E-8-β-Carboxamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.