Description

Gramicidin A, Leu(2)- CAS NO 80713-06-0 is a specific, high-purity variant of the linear pentadecapeptide antibiotic gramicidin A, characterized by the substitution of leucine at the second position. This compound is valued for its potent and selective ionophoric activity, forming channels in lipid membranes to disrupt ion gradients in target cells. It is an essential research-grade biochemical for the study of membrane biophysics and antimicrobial mechanisms, serving pharmaceutical R&D, academic research, and specialized biotech applications.

Application

• Biochemical Research: A critical tool for studying ion channel formation, membrane permeability, and the biophysical properties of lipid bilayers.
• Antimicrobial Mechanism Studies: Used as a reference standard to investigate the action of pore-forming antibiotics against Gram-positive bacteria.
• Pharmaceutical Development: Serves as a model compound in the research and development of novel antimicrobial agents and drug delivery systems.
• Cell Biology & Physiology: Applied in experiments to modulate intracellular ion concentrations (e.g., Na+, K+) and study subsequent cellular responses.
• Biophysical Assays: Utilized in fluorescence, electrophysiology (e.g., patch-clamp), and planar lipid bilayer experiments to characterize channel kinetics.
• Reference Standard: Employed as a high-purity calibrant in analytical methods such as HPLC and mass spectrometry for quality control of related peptides.

Basic Information

Item	Detail
Product Name	Gramicidin A, Leu(2)-
CAS No.	80713-06-0
Molecular Formula	C99H140N20O17
Molecular Weight	1882.3 g/mol
Synonyms	Gramicidin A (Leu-2); [Leu2]Gramicidin A; Gramicidin A, Leu2- isomer; Val-Gly-Ala-Leu-Ala-Val-Val-Trp-Leu-Trp-Leu-Trp-Leu-Trp-NH-CH2-CH2-OH; Linear Gramicidin A (Leu2); Gramicidin A Leu(2) variant; Pentadecapeptide antibiotic A (Leu2)
EINECS	Contact for details

Quality Control

Our Gramicidin A, Leu(2)- is produced and tested under stringent quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, with specifications tailored to meet the exacting requirements of laboratory use.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive); ensure containers are sealed immediately after use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.