Description

Dehydro Rifaximin is a semi-synthetic derivative of the broad-spectrum antibiotic rifamycin, specifically engineered for enhanced stability and targeted activity. This compound is of significant interest in pharmaceutical research and development due to its potential as a key intermediate or active pharmaceutical ingredient (API) in advanced therapeutic formulations. It is primarily sought by manufacturers and R&D laboratories in the pharmaceutical and biotechnology sectors for the development of novel gastrointestinal and anti-infective treatments.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of next-generation rifamycin-based antibiotics.
• Active Pharmaceutical Ingredient (API) R&D: Used in research for developing new drug formulations targeting bacterial infections, particularly in the gut.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Biochemical Research: Utilized in microbiological and pharmacological studies to investigate mechanisms of action against bacterial RNA polymerase.
• Process Chemistry: Acts as a starting material or intermediate in scale-up and process optimization for API manufacturing.

Basic Information

Product Name	Dehydro Rifaximin
CAS No.	80621-76-7
Molecular Formula	C43H51N3O11
Molecular Weight	785.89 g/mol
Synonyms	Dehydro Rifaximin; Rifaximin Impurity F; (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26S,27S,28E)-5,6,21,23,25-Pentahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione; L 105; Rifaximin Dehydro Derivative; Rifamycin L 105; Antibiotic L 105
EINECS	Contact for details

Quality Control

Our Dehydro Rifaximin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and stringent control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with cGMP and relevant pharmaceutical guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and purity. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	Orange-red to reddish-brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.