Description

Polymyxin Ile-B1 is a specific, high-purity derivative of the polymyxin class of polypeptide antibiotics. This compound is critical for research and development in the pharmaceutical and biotechnology sectors, particularly in the study of antibiotic mechanisms and resistance. It serves as a valuable reference standard and intermediate for scientists and manufacturers focused on novel anti-infective therapies and quality control of related pharmaceutical products.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of polymyxin-based drugs in research and quality control laboratories.
• Biochemical Research: Employed in studies investigating the structure-activity relationships, mechanism of action, and bacterial resistance pathways of polymyxin antibiotics.
• API Intermediate: Serves as a key building block or precursor in the synthetic or semi-synthetic production of specialized antibiotic formulations.
• Microbiological Studies: Applied in in-vitro assays to evaluate antimicrobial potency and spectrum against Gram-negative pathogens.
• Method Development: Utilized for developing and validating analytical methods such as HPLC, LC-MS, and microbiological assays in compliance with pharmacopeial guidelines.

Basic Information

Product Name	Polymyxin Ile-B1
CAS No.	80469-10-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Polymyxin B1-Ile; Ile-Polymyxin B1; Polymyxin B1 Isoleucine variant; Antibiotic Aerosporin variant; Polymyxin B component B1 (Ile); [Ile]Polymyxin B1; Polymyxin B1 (Ile-6)
EINECS	Contact for details

Quality Control

Our Polymyxin Ile-B1 is produced and tested under strict quality management systems. Each batch undergoes comprehensive analysis to ensure high purity and consistency, meeting the exacting standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profiles is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccated or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.