Description

Tri-Sil(R) Z is a specialized organosilicon compound widely utilized as a versatile reagent and intermediate in advanced chemical synthesis. Its primary value lies in its ability to introduce silyl protecting groups, which are essential for the selective modification of sensitive functional groups in complex molecules. This product is critical for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where precise molecular control is paramount.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) for protecting hydroxyl groups during multi-step reactions.
• Agrochemical Synthesis: Serves as a key reagent in the production of advanced pesticides and herbicides requiring selective functional group protection.
• Peptide Chemistry: Employed for the protection of serine, threonine, and tyrosine side chains in solid-phase and solution-phase peptide synthesis.
• Nucleoside & Carbohydrate Chemistry: Facilitates the selective silylation of sugar hydroxyl groups in the synthesis of nucleoside analogs and complex carbohydrates.
• Material Science Precursor: Acts as a building block or surface modifying agent in the development of specialty silicones and advanced polymeric materials.
• Analytical Derivatization: Used to prepare volatile derivatives of polar compounds for analysis by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS).

Basic Information

Product Name	Tri-Sil(R) Z
CAS No.	8077-35-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	N,O-Bis(trimethylsilyl)acetamide; BSA; N,O-Bis(trimethylsilyl)acetamide (contains Trimethylchlorosilane); Acetamide, N,N-bis(trimethylsilyl)-; BSTA; Silylating Agent Z; TMSA (related derivative); Hexamethyldisilazane reagent mixture
EINECS	Contact for details

Quality Control

Every batch of Tri-Sil(R) Z is manufactured and tested under a strict quality management system. We ensure the product meets high-purity standards suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to standard
Assay (GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Chloride Content (as Cl)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.