Description

Colistimethate Sodium is a polymyxin antibiotic, specifically the sodium salt of the methanesulfonate derivative of colistin. This compound is critically important as a last-resort therapeutic agent for treating multidrug-resistant Gram-negative bacterial infections. It is primarily required by the pharmaceutical industry for the formulation of injectable antibiotics, serving hospitals and healthcare providers globally.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the manufacture of sterile injectable formulations for systemic administration.
• Treatment of Severe Infections: Critical for infections caused by multidrug-resistant pathogens like Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae.
• Hospital-Acquired Pneumonia (HAP) & Ventilator-Associated Pneumonia (VAP): A key component in treatment protocols for these serious respiratory infections.
• Cystic Fibrosis Management: Used in inhalation therapy to manage chronic pulmonary infections in cystic fibrosis patients.
• Bactericidal Agent in Topical Formulations: Incorporated into creams, ointments, or powders for treating localized skin and wound infections.
• Veterinary Medicine: Used in certain veterinary applications to treat bacterial infections in animals.
• Research & Development: Serves as a reference standard and active component in microbiological and pharmacological research.

Basic Information

Product Name	Colistimethate Sodium
CAS No.	8068-37-9
Molecular Formula	C58H105N16Na5O28S5
Molecular Weight	1749.8 g/mol (approx.)
Synonyms	Colistin Methanesulfonate Sodium; Colistimethate; Pentasodium Colistimethanesulfonate; Colistin Sulfomethate Sodium; Polymyxin E Methanesulfonate Sodium; Coly-Mycin M; Colomycin; CMS-Na; Multimycin
EINECS	Contact for details

Quality Control

Our Colistimethate Sodium is manufactured and tested to meet stringent pharmaceutical standards. Quality assurance protocols are designed to ensure identity, purity, potency, and safety, with compliance to relevant pharmacopoeial monographs such as USP and EP. A comprehensive Certificate of Analysis (COA) detailing assay, impurities, microbial limits, and other critical parameters is provided with each batch to guarantee supply reliability and regulatory compliance for our global B2B partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as specified. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to slightly yellow powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (Anhydrous Basis)	Not less than 77.0% (as Colistin Base)
pH (1% Solution)	6.0 - 8.0
Water Content	Not more than 7.0%
Related Substances (HPLC)	Meets requirement
Bacterial Endotoxins	< 2.5 EU/mg
Sterility (for sterile grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.