Description

Colistin Sodium Methanesulfonate is a polymyxin antibiotic complex derived from *Bacillus polymyxa* var. *colistinus*, supplied as a high-purity sodium salt. This compound is critically important for its potent bactericidal activity against multidrug-resistant Gram-negative pathogens. It is essential for pharmaceutical manufacturers, veterinary medicine producers, and research institutions developing treatments for serious infections where other antibiotics have failed.

Application

• Pharmaceutical API: Used as the active pharmaceutical ingredient (API) in injectable formulations for treating severe systemic infections caused by Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter baumannii.
• Veterinary Medicine: A key component in medicated feed additives and injectable solutions for the prevention and treatment of bacterial enteritis and respiratory diseases in livestock and poultry.
• Research & Development: Serves as a critical reference standard and research tool in microbiology labs for studying antibiotic resistance mechanisms and developing novel combination therapies.
• Topical Formulations: Incorporated into creams, ointments, and powders for the treatment of localized skin, ear, and eye infections.
• Cell Culture & Biotechnology: Used in selective media to prevent bacterial contamination in cell culture and fermentation processes.

Basic Information

Product Name	Colistin Sodium Methanesulfonate
CAS No.	8068-28-8
Molecular Formula	C58H105N16O28S5Na5 (representative)
Molecular Weight	~1749.8 g/mol (representative)
Synonyms	Colistimethate Sodium; Colistin Methanesulfonate Sodium Salt; Pentasodium Colistin Methanesulfonate; Coly-Mycin M; Polymyxin E Sodium Methanesulfonate; CMS-Na; Colomycin Injection; Colistin Sulphomethate Sodium
EINECS	232-521-1

Quality Control

Our Colistin Sodium Methanesulfonate is manufactured under strict quality management systems. Each batch is tested to ensure it meets stringent specifications for identity, potency, and purity, aligning with pharmacopeial standards. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological quality is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to slightly yellow powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (Anhydrous Basis)	Not less than 77.0% (as Colistin Base)
pH (1% Solution)	6.5 - 8.5
Water Content (KF)	Not more than 5.0%
Related Substances (HPLC)	Total impurities: Not more than 5.0% Any individual impurity: Not more than 2.0%
Residual Solvents	Complies with ICH Q3C
Bacterial Endotoxins	Less than 0.067 EU/µg
Sterility (for sterile grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.