Description

Bicillin-3 is a long-acting, injectable antibiotic formulation belonging to the penicillin class, specifically designed as a combination of benzathine penicillin G and procaine penicillin G. This product is critical for ensuring reliable, sustained therapeutic levels of penicillin, offering a significant advantage in treatment regimens requiring prolonged antibiotic coverage. It is primarily utilized in the pharmaceutical and veterinary sectors for the treatment and prophylaxis of susceptible bacterial infections where compliance with a multi-dose regimen is challenging.

Application

• Human Pharmaceutical Formulations: Used in the treatment of streptococcal infections (e.g., strep throat, scarlet fever), syphilis, and rheumatic fever prophylaxis, where a single, long-acting dose is required.
• Veterinary Medicine: Employed for the treatment of bacterial infections in livestock, such as swine, cattle, and poultry, benefiting from its sustained-release properties.
• Active Pharmaceutical Ingredient (API): Serves as the key therapeutic component in the manufacture of sterile injectable suspensions for intramuscular administration.
• Prophylactic Treatment: Essential in public health and institutional settings for the prevention of disease outbreaks caused by penicillin-susceptible organisms.

Basic Information

Product Name	Bicillin-3
CAS No.	8067-92-3
Molecular Formula	Mixture of (C16H18N2O4S)2 · C16H20N2 · 4H2O and C16H18N2O4S · C13H20N2O2 · H2O
Molecular Weight	Mixture (Contact for details)
Synonyms	Penicillin G Benzathine and Penicillin G Procaine Combination; Benzathine Benzylpenicillin / Procaine Benzylpenicillin; Penicillin G Benzathine and Procaine Combined; Fortified Procaine Penicillin; Dual-Penicillin Suspension; Long-acting Penicillin Combination; Antibiotic Depot Formulation
EINECS	Contact for details

Quality Control

Our Bicillin-3 is manufactured under strict quality systems to ensure it meets the rigorous standards required for pharmaceutical actives. Quality assurance includes comprehensive testing for potency, purity, sterility (where applicable), and particle size distribution. Certificates of Analysis (COA) are provided with each batch, documenting compliance with relevant pharmacopeial monographs such as USP or BP.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be protected from excessive humidity to maintain stability and potency.

Specification

Item	Specification
Description	White to off-white crystalline powder or suspension
Identification (IR)	Conforms to standard
Assay (HPLC)	90.0% - 110.0% of labeled penicillin G units
Ratio (Benzathine:Procaine)	As per labeled claim
Water Content	≤ 5.0% (Karl Fischer)
pH (in suspension)	5.0 - 7.5
Bacterial Endotoxins	< 0.25 EU/mg (where applicable)
Sterility	Conforms to test (for sterile grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.