Description

Benzatropine CAS NO 86-13-5 is a synthetic anticholinergic agent belonging to the class of tropane alkaloids. This compound is of significant commercial and pharmaceutical importance due to its potent pharmacological activity as a muscarinic acetylcholine receptor antagonist. It is primarily required by the pharmaceutical industry for the formulation of active pharmaceutical ingredients (APIs) used in the treatment of Parkinson's disease and the management of extrapyramidal side effects caused by antipsychotic medications.

Application

• Pharmaceutical API: Primary use as an active pharmaceutical ingredient in medications for Parkinson's disease and drug-induced movement disorders.
• Neurological Research: A critical reference standard and tool compound in neuroscience research for studying cholinergic pathways and receptor mechanisms.
• Chemical Synthesis: Serves as a key intermediate or precursor in the synthesis of more complex tropane-based pharmaceutical molecules.
• Analytical Standard: Used as a high-purity certified reference material (CRM) in analytical laboratories for method development, validation, and quality control testing.
• Veterinary Medicine: Potential application in veterinary pharmaceuticals for managing specific neurological conditions in animals.

Basic Information

Item	Detail
Product Name	Benzatropine
CAS No.	86-13-5
Molecular Formula	C21H25NO
Molecular Weight	307.43 g/mol
Synonyms	Benzatropine Mesylate; Benztropine; 3-(Diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane; Cogentin (brand name); Tropine Benzohydryl Ether; Endophrine; Benzotropine; 8-Methyl-3-(phenylphenylmethoxy)-8-azabicyclo[3.2.1]octane
EINECS	201-652-7

Quality Control

Our Benzatropine is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability. We provide material that meets or exceeds pharmaceutical-grade standards, with comprehensive testing including identity, purity, and impurity profiling. A detailed Certificate of Analysis (COA), confirming compliance with agreed specifications, is supplied with every shipment. Our quality systems support compliance with cGMP, ICH Q7, and other relevant global regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.