Description

(1R,3S)-Solifenacin Succinate CAS NO 774517-20-3 is the specific, pharmacologically active enantiomer of the antimuscarinic agent solifenacin succinate. This high-purity chiral intermediate is critical for the synthesis of advanced pharmaceutical active ingredients (APIs) targeting overactive bladder (OAB) syndrome. It is essential for pharmaceutical manufacturers and advanced research institutions developing enantiomerically pure therapeutics, where stereochemical integrity directly impacts drug efficacy and safety profiles.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Primary use as a key chiral building block in the commercial production of solifenacin succinate API.
• Pharmaceutical R&D: Crucial for process development, method validation, and formulation studies of enantiomerically pure antimuscarinic drugs.
• Reference Standard: Serves as a high-purity chemical reference standard (CRS) for quality control and analytical method development in pharmacopoeial testing.
• Clinical Trial Material: Used in the manufacture of investigational medicinal products for clinical studies.
• Advanced Intermediate: Employed in the synthesis of novel derivatives and prodrugs for new therapeutic applications.

Basic Information

Product Name	(1R,3S)-Solifenacin Succinate
CAS No.	774517-20-3
Molecular Formula	C23H26N2O2 • C4H6O4
Molecular Weight	480.55 g/mol
Synonyms	(1R,3S)-1-Azabicyclo[2.2.2]oct-8-yl (1S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate succinate; (3R)-1-Azabicyclo[2.2.2]octan-3-yl (1S)-2,3-dihydro-1-phenyl-1H-isoindole-1-carboxylate butanedioate; Vesicare Impurity; Solifenacin Related Compound; YM905 Succinate; (1R,3S)-YM905 Succinate
EINECS	Contact for details

Quality Control

Our (1R,3S)-Solifenacin Succinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure compliance with pharmaceutical-grade standards. A detailed Certificate of Analysis (COA) providing batch-specific results for identity, purity, and impurities is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be protected from humidity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Enantiomeric Excess)	≥ 99.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.