Description

5-Bromomethyl-2-Fluorobenzoic Acid is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its core value lies in the strategic combination of a reactive bromomethyl group and a fluorine substituent on the benzoic acid scaffold, enabling precise molecular modifications. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs), especially in the development of fluorinated drug candidates targeting CNS disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a critical starting material for synthesizing fluorinated aromatic cores used in electronic display technologies and organic light-emitting diodes.
• Cross-Coupling Reactions: The bromomethyl group acts as a versatile handle for further functionalization via Suzuki, Sonogashira, or other palladium-catalyzed cross-coupling reactions.
• Peptidomimetic & PROTAC Development: Employed in medicinal chemistry for constructing linkers and aromatic components in complex molecules like proteolysis-targeting chimeras (PROTACs).
• Chemical Biology Probes: Useful for the synthesis of fluorescent tags, affinity labels, and other molecular probes used in biochemical research and diagnostic assays.

Basic Information

Item	Details
Product Name	5-Bromomethyl-2-Fluorobenzoic Acid
CAS No.	773100-76-8
Molecular Formula	C8H6BrFO2
Molecular Weight	233.04 g/mol
Synonyms	2-Fluoro-5-(bromomethyl)benzoic Acid; 5-(Bromomethyl)-2-fluorobenzoic Acid; Benzoic acid, 5-(bromomethyl)-2-fluoro-; 2-Fluoro-5-bromomethylbenzoic Acid; 5-Bromomethyl-2-fluorobenzoic Acid; 773100-76-8; 5-(Bromomethyl)-2-fluorobenzoic acid
EINECS	Contact for details

Quality Control

Our 5-Bromomethyl-2-Fluorobenzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF for moisture content, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly sealed due to the compound's sensitivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.