Description

5-(4-Trifluoromethylphenyl)-Picolinic Acid is a high-value trifluoromethylated heterocyclic building block. This compound is critical for the development of advanced materials and active pharmaceutical ingredients (APIs) due to the unique properties imparted by the trifluoromethyl group. It is primarily sought by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for synthesis and process development.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in kinase inhibitor and anti-inflammatory agent discovery.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand for Catalysis: Serves as a precursor for constructing specialized ligands in transition metal catalysis for fine chemical synthesis.
• Material Science Research: Employed in the development of organic electronic materials and liquid crystals due to its aromatic and fluorinated structure.
• Chemical Biology Probes: Utilized as a building block for creating molecular probes to study biological processes.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up production under cGMP or ISO standards.

Basic Information

Product Name	5-(4-Trifluoromethylphenyl)-Picolinic Acid
CAS No.	762287-48-9
Molecular Formula	C13H8F3NO2
Molecular Weight	267.21 g/mol
Synonyms	5-[4-(Trifluoromethyl)phenyl]pyridine-2-carboxylic acid; 2-Pyridinecarboxylic acid, 5-[4-(trifluoromethyl)phenyl]-; 5-(4-Trifluoromethylphenyl)-2-pyridinecarboxylic acid; 5-(p-Trifluoromethylphenyl)picolinic acid
EINECS	Contact for details

Quality Control

Our production of 5-(4-Trifluoromethylphenyl)-Picolinic Acid adheres to stringent quality management protocols. Each batch is characterized and tested to ensure identity, purity, and consistency, meeting the exacting standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity (typically >97% by HPLC), identity confirmation (IR, NMR), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.