Description

4-Thia-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid, 3-Ethyl-6-Hydroxy-7-Oxo-, cis- (9Ci) is a specialized heterocyclic compound belonging to the class of penem derivatives, which are of significant interest in medicinal chemistry. This high-purity intermediate is crucial for the research and development of novel β-lactam antibiotics and enzyme inhibitors. It serves as a key building block for pharmaceutical chemists and R&D teams focused on creating new therapeutic agents targeting bacterial resistance.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel penem and carbapenem antibiotics.
• Medicinal Chemistry Research: Used as a scaffold for designing and testing new molecules with antibacterial or β-lactamase inhibitory activity.
• Biochemical Studies: Serves as a reference standard or probe in enzymatic studies related to bacterial cell wall synthesis.
• Academic & Institutional R&D: Utilized in university and research institute laboratories for advanced organic synthesis projects.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects.
• Process Development: Employed in the scale-up and optimization of synthetic routes for complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	4-Thia-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid, 3-Ethyl-6-Hydroxy-7-Oxo-, cis- (9Ci)
CAS No.	761353-12-2
Molecular Formula	C9H11NO4S
Molecular Weight	229.25 g/mol
Synonyms	cis-3-Ethyl-6-hydroxy-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; (5R,6S)-3-Ethyl-6-hydroxy-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; Penem derivative intermediate; 3-Ethyl penem carboxylic acid; 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-ethyl-6-hydroxy-7-oxo-, (5R-cis)-; 761353-12-2; (5R,6S)-3-Ethyl-6-hydroxy-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and regulatory needs with documentation suitable for use in cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.