Description

3,6-Difluoro-2-Hydroxybenzoic Acid is a fluorinated benzoic acid derivative that serves as a versatile and valuable building block in advanced organic synthesis. Its unique structure, featuring both a carboxylic acid and a phenolic hydroxyl group on a difluorinated aromatic ring, makes it a critical intermediate for creating complex molecules with tailored properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to introduce fluorine atoms and specific functional groups to modulate the bioactivity, metabolic stability, and physical characteristics of target compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluoro-hydroxybenzoate moiety can enhance efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic materials, contributing to improved performance in display and lighting technologies.
• Polymer Modification: Acts as a monomer or functionalization agent for creating specialty polymers with enhanced chemical resistance, thermal stability, or surface properties.
• Complex Ligand Synthesis: Employed in the preparation of chelating agents and ligands for catalysis and metal-organic frameworks (MOFs).
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, including cross-coupling and fluorination reactions.

Basic Information

Product Name	3,6-Difluoro-2-Hydroxybenzoic Acid
CAS No.	749230-37-3
Molecular Formula	C7H4F2O3
Molecular Weight	174.10 g/mol
Synonyms	2-Hydroxy-3,6-difluorobenzoic Acid; 3,6-Difluorosalicylic Acid; 3,6-Difluoro-2-hydroxybenzoic acid; Benzoic acid, 3,6-difluoro-2-hydroxy-; 749230-37-3; 3,6-DFHBA
EINECS	Contact for details

Quality Control

Our 3,6-Difluoro-2-Hydroxybenzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and industrial synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment upon request. We support compliance with global regulatory frameworks, including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. Due to its acid nature, ensure appropriate secondary containment is used.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.