Description

(1R,3R)-Solifenacin Succinate 2 is a high-purity, stereochemically defined active pharmaceutical ingredient (API). This compound is the key enantiomer in the synthesis of Solifenacin Succinate, a potent muscarinic receptor antagonist. It is essential for pharmaceutical manufacturers and research institutions developing and producing treatments for overactive bladder (OAB) syndrome. Consistent quality and reliable supply of this critical intermediate are paramount for ensuring the efficacy and safety of the final drug product.

Application

• Pharmaceutical Intermediate: Primary use as a critical chiral building block in the synthesis of the API Solifenacin Succinate.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as the direct precursor in GMP-compliant production processes for finished dosage forms.
• Research & Development: Used in pharmacological studies, process chemistry optimization, and the development of new synthetic routes.
• Analytical Reference Standard: Employed as a high-purity standard for HPLC, LC-MS, and other analytical methods for quality control and method validation.
• Formulation Development: Supports pre-formulation and formulation studies for various drug delivery systems.

Basic Information

Product Name	(1R,3R)-Solifenacin Succinate 2
CAS No.	740780-79-4
Molecular Formula	C23H26N2O2 • C4H6O4
Molecular Weight	480.55 g/mol (for succinate salt)
Synonyms	(1R,3R)-1-Azabicyclo[2.2.2]oct-8-yl (1S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate succinate; (3R)-1-Azabicyclo[2.2.2]octan-3-yl (1S)-2,3-dihydro-1-phenyl-1H-isoindole-1-carboxylate butanedioate; Solifenacin Succinate Intermediate; (1R,3R)-Solifenacin base succinate salt; Vesicare Intermediate; YM905 Intermediate
EINECS	Contact for details

Quality Control

Our (1R,3R)-Solifenacin Succinate 2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific pharmacopeial standards (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (1R,3R)-isomer
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.