Description

4'-Trifluoromethoxy-Biphenyl-4-Carboxylic Acid is a high-purity, multi-functional biphenyl derivative characterized by its trifluoromethoxy and carboxylic acid functional groups. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block in modern organic synthesis, enabling the introduction of unique steric and electronic properties into target molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the stability imparted by the trifluoromethoxy group.
• Liquid Crystal & OLED Materials: Acts as a core building block for high-performance electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance thermal stability, chemical resistance, and specific optical properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Heck) and as a precursor for amides, esters, and other derivatives in medicinal chemistry.
• Chemical Research & Development: Serves as a standard or reference compound in analytical method development and structure-activity relationship (SAR) studies.

Basic Information

Product Name	4'-Trifluoromethoxy-Biphenyl-4-Carboxylic Acid
CAS No.	728919-11-7
Molecular Formula	C14H9F3O3
Molecular Weight	282.22 g/mol
Synonyms	[4-(Trifluoromethoxy)phenyl]benzoic acid; 4'-(Trifluoromethoxy)[1,1'-biphenyl]-4-carboxylic acid; Biphenyl-4-carboxylic acid, 4'-(trifluoromethoxy)-; 4-Carboxy-4'-(trifluoromethoxy)biphenyl; 4'-Trifluoromethoxybiphenyl-4-carboxylic acid; 4-(4-Trifluoromethoxyphenyl)benzoic acid; 4'-Trifluoromethoxy[1,1'-biphenyl]-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4'-Trifluoromethoxy-Biphenyl-4-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly closed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.