Description

Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-Nh2 is a synthetic, fluorogenic peptide substrate designed for the specific detection and study of matrix metalloproteinase (MMP) activity, particularly collagenases. This compound matters as a critical research tool for biochemical and pharmaceutical development, enabling precise kinetic analysis and inhibitor screening in enzymatic assays. It is primarily needed by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in oncology, inflammation, and tissue remodeling research.

Application

• Biochemical Research: As a specific fluorogenic substrate for MMP-1, MMP-8, MMP-13, and related collagenases in enzyme kinetics studies.
• Drug Discovery & Screening: High-throughput screening (HTS) of potential MMP inhibitor compounds for therapeutic development in cancer and arthritis.
• Diagnostic Development: A key component in developing in vitro diagnostic (IVD) assays to measure MMP activity in biological samples.
• Cell Biology & Tissue Engineering: Studying extracellular matrix (ECM) degradation and cellular invasion processes in relevant disease models.
• Academic Research: Investigating the role of specific MMPs in physiological and pathological processes.
• Quality Control: Used as a reference standard in the production and validation of other MMP-targeting reagents and kits.

Basic Information

Product Name	Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-Nh2
CAS No.	720710-69-0
Molecular Formula	C55H81N15O15
Molecular Weight	1184.34 g/mol
Synonyms	MMP Substrate I; Mca-PLGL-Dpa-AR-NH2; Fluorogenic MMP Substrate; (7-Methoxycoumarin-4-yl)acetyl-Lys-Pro-Leu-Gly-Leu-[N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-Ala-Arg-NH2; Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2; Dnp-Peptide; Collagenase Substrate; MMP Fluorogenic Peptide Substrate 1
EINECS	Contact for details

Quality Control

Our Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-Nh2 is manufactured under strict quality protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substance profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.