Description

Pimavanserin is a highly selective serotonin 5-HT2A receptor inverse agonist and antagonist. This compound is of significant commercial and research interest due to its specific pharmacological profile, making it a critical intermediate and reference standard in the development of novel central nervous system (CNS) therapeutics. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) for the development and quality control of antipsychotic medications.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control testing in API and finished drug product manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key synthetic building block in the commercial production of the antipsychotic drug Pimavanserin Tartrate.
• Pharmacological Research: Employed in in vitro and in vivo studies to investigate 5-HT2A receptor function and its role in neurological and psychiatric conditions.
• Drug Discovery & Development: Acts as a lead compound or a structural template for designing new chemical entities targeting serotonin receptors for CNS disorders.
• Regulatory Compliance & Documentation: Essential for preparing regulatory submission dossiers (e.g., for FDA, EMA) requiring detailed characterization data of the drug substance.

Basic Information

Product Name	Pimavanserin
CAS No.	706779-91-1
Molecular Formula	C25H34FN3O2
Molecular Weight	427.56 g/mol
Synonyms	1-(4-Fluorobenzyl)-3-(4-isobutoxybenzyl)-8-methyl-3,8-diazabicyclo[3.2.1]octane; ACP-103; N-(4-Fluorophenylmethyl)-1-(1-methyl-4-piperidinyl)-1H-indole-3-ethanamine; UNII-84DJ9U3W8S; Pimavanserin base; Pimavanserin (free base)
EINECS	Contact for details

Quality Control

Our Pimavanserin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting high-grade standards suitable for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.