Description

trans-2-(3,5-Difluorophenyl)Cyclopropane-1-Carboxylic Acid is a high-value, fluorinated cyclopropane carboxylic acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring a rigid cyclopropane ring and a difluorinated aromatic system, is essential for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of active pharmaceutical ingredients (APIs), particularly in areas like enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the design and synthesis of novel herbicides, fungicides, and insecticides, where the difluorophenyl and cyclopropane motifs can enhance potency and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis or as a scaffold in medicinal chemistry for structure-activity relationship (SAR) studies.
• Material Science Research: Investigated as a monomer or building block for advanced polymers and liquid crystals, leveraging its rigid, fluorinated structure.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	trans-2-(3,5-Difluorophenyl)Cyclopropane-1-Carboxylic Acid
CAS No.	705250-91-5
Molecular Formula	C10H8F2O2
Molecular Weight	198.17 g/mol
Synonyms	(1R,2S)-2-(3,5-Difluorophenyl)cyclopropanecarboxylic Acid; (1S,2R)-2-(3,5-Difluorophenyl)cyclopropanecarboxylic Acid; trans-2-(3,5-Difluorophenyl)cyclopropanecarboxylic Acid; 2-(3,5-Difluorophenyl)cyclopropanecarboxylic Acid; 705250-91-5; Cyclopropanecarboxylic acid, 2-(3,5-difluorophenyl)-, trans-; 3,5-Difluorophenylcyclopropanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our trans-2-(3,5-Difluorophenyl)Cyclopropane-1-Carboxylic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up. We provide comprehensive analytical data including HPLC purity, chiral purity, and identification via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications is available with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.